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Some viral diseases are hidden, complicating our lives only by the manifestation of external signs. Such pathologies include herpetic infection, manifested by crusts in the corner of the mouth, on the lips, or the mucous membrane of the oral cavity (less often the area of the genitals, abdomen, and back is affected).

Рerpes looks quite harmless externally, hence such a frivolous attitude to pathology. It is just a little ulcer that doesn’t cause much trouble. After a course of treatment with zinc ointment or other drying agents, the sore disappears but appears again and again when the immune forces of the body decrease.

This indicates that the virus is constantly living in the human body, and is activated during the period when the protective forces are reduced. In the latent state, the harmful microorganism continues to destroy the body, adversely affecting, first of all, the immune system. Often, cracks appearing in the corners of the mouth, red peeling spots, or brownish crusts are signs of herpes infection.

One of the effective drugs used in the treatment of diseases caused by the herpes virus is Valacyclovir, which is the l-valine ester of acyclovir.

Pharmacological properties

Valacyclovir (Valtrex) is a drug used to treat diseases caused by the herpes virus. In the body, it is almost completely transformed into acyclovir and valine as a result of biochemical reactions.

Valaciclovir is an effective blocker of herpes viruses of the 1st and 2nd type, Varicella zoster, cytomegalovirus, and some other pathogens of viral nature. Under the influence of the phosphorylation process, acyclovir is converted from mono form to triphosphate, which is introduced into viral DNA and stops the process of cell division.

The effectiveness of the drug depends largely on the state of immunity. Scientists have revealed that people with high immune status rarely have diseases caused by a drug-insensitive virus.


The list of infections includes the following types of diseases:

herpes(lichen) shingles (herpes zoster); genital herpes; herpes on the lips (lip fever); relapses of skin infections (causative agent of herpes simplex); prevention of cytomegalovirus infection (after operations for transplantation of donor organs).

Method of reception

The scheme of treatment of infectious diseases caused by the herpes virus is as follows.

The patient takes 1 pill 2 times a day (1 tablet-500 mg). In сase of primary infection, the duration of therapy is 5-10 days, in case of relapses — 3-5 days. The effectiveness of the drug regimen depends on the time of treatment (the earlier the drug is started, the more successful the therapy will be).

Labile herpes. Take the drug Valtrex when the first symptoms of the disease (burning, tingling, itching, swelling of the skin in the area of the introduction of the virus). The drug is prescribed at the dosage of 4 pills 2 times a day (the dose is 2,000 mg). The second time the drug is taken within 10-12 hours after the first reception. The next day, the drug is not prescribed because it is proved that its further use does not affect the clinical effectiveness of treatment.

Prevention of sexual transmission. If you want to reduce the likelihood of infection with genital herpes sexual partner (provided that he has a normally functioning immune system), he is prescribed to take the drug at a dose of 500 mg once a day.

The dosage in each case is adjusted for patients with reduced immunity. The prophylactic reception of the drug Valtrex is justified if at least one case of herpes infection has been recorded.

Patients undergoing treatment with hemodialysis are prescribed Valtrex after the procedure. Constant monitoring of creatinine clearance is mandatory, especially after tissue and organ transplants (transplantation).

A patient with liver pathologies, including cirrhosis, does not adjust the dose of the drug. Elderly people reduce the dose to avoid the development of complications from the kidneys. It is necessary to monitor compliance with the water regime, preventing fluid deficiency in the body.

Side effects

Most of the negative reactions that can develop in the background of a prescribed treatment by a doctor are reversible. In medical practice, cases of negative effects developing from the organs and functional systems (digestive, nervous, vascular, hematopoietic, and immune) have been recorded.

The most common reactions are headache, nausea, vomiting, weakness, from the hematopoietic organs-thrombocytopenia, anemia, rarely-leukopenia.